He was taking pioglitazone for diabetes, a drug that makes some people gain weight. Dr. Aronne replaced it with Invokana, a diabetes drug that can contribute to weight loss — and Mr. Goldshine lost a small amount. Then Dr. Aronne added a drug that combines bupropion, an antidepressant, and naltrexone, a drug used to combat cravings for drugs like opioids.
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